Getting Closer to a Cure
Posted 2/01/2001
Prognosis
Alzheimer's disease is a debilitating and progressive brain condition that usually strikes people over 65 years of age. About 4 million Americans are stricken with
this disease, and an estimated 22 million will have Alzheimer’s by 2025. Common symptoms include memory loss, confusion, delusions, insomnia, and anxiety.
The disease causes deposits and tangles on nerve cells in the brain. This disrupts the way the nerve cells connect preventing the brain from receiving memory-based
information. There is no known cure, however some drugs have been developed to temporarily slow down the progression, and reduce the symptoms of Alzheimer’.
Gene Link
Researchers have discovered a gene known as APoE-4, that has been linked to Alzheimer's disease. Apparently, APoE receptors are linked to abnormal proteins via nerve cells. These
are the proteins that cause the deposits and tangles in the brain. However, approximately half of the people who are afflicted with Alzheimer's disease do not have the APoE-4 gene. In
December 2000, a team of scientists at the Washington School of Medicine in St. Louis, Missouri found new evidence that points to a new gene linked to the disease. This new gene is located
on chromosome 10 and possibly causes the plaques that create lesions on the brain. The protein, produced by this gene, can build up in an individual's system for over 50 or 60 years
and cause inflammation.
Research and Treatment
In June 2000, it was first announced by scientists at the Harvard Medical School that there may be a genetic link in Alzheimer's disease. This is important
news for families that have relatives with the disease. Many cases show that relatives of Alzheimer's patients are at risk of developing the disease.
While the identification of a gene that causes Alzheimer's disease will not be a cure, it can help in identifying whether a person is at risk for Alzheimer's Disease.
Also, with further knowledge of the exact cause of the disease, research could lead to new discoveries on how to treat Alzheimer's.
Activity
Use the Internet links listed below to learn more about Alzheimer's disease and how it deteriorates the brain. Use this information to develop a class presentation
about methods used to treat the disease and care for Alzheimer's patients.
References
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